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Related Experiment Video

Updated: Jul 8, 2026

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model

Published on: August 11, 2023

Mortality and reduced growth hormone secretion.

Kirstine Stochholm¹, Jens Christiansen, Torben Laursen

¹Department of Endocrinology, Aarhus University Hospital, Aarhus, Denmark. Stochholm@dadlnet.dk

Hormone Research

|February 7, 2008

Summary

Mortality rates for growth hormone deficiency (GHD) patients are often increased, particularly in females. While growth hormone (GH) treatment may normalize mortality in some cases, more research is needed.

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Area of Science:

Endocrinology
Epidemiology
Public Health

Background:

Limited data exist on mortality rates for patients with growth hormone deficiency (GHD), though hypopituitary patients show increased mortality compared to the general population.
Cardiovascular disease is a suspected primary cause of death, with cancer statistics potentially affected by pituitary disease-related malignancies.
Reported differences in mortality rates between females and males necessitate further investigation.

Purpose of the Study:

To review and synthesize existing epidemiological data on mortality rates in hypopituitary and GHD patients.
To identify potential factors influencing mortality, including sex and age of GHD onset.
To evaluate the impact of growth hormone (GH) treatment on mortality rates.

Main Methods:

Systematic review and analysis of published epidemiological studies focusing on mortality in hypopituitary and GHD populations.
Inclusion of studies examining mortality in both treated and untreated GHD patients.

Main Results:

Most reviewed studies indicate an elevated mortality rate in hypopituitary and GHD patients.
Female patients generally exhibit higher mortality rates compared to male patients.
Two studies suggest that GH treatment may lead to mortality rates comparable to the general population, though data are limited.

Conclusions:

An increased mortality rate in hypopituitary patients is established, but definitive causes require further research.
Interpreting the impact of GH treatment on mortality must be done cautiously due to limited data and study design constraints.
Additional high-quality research is essential for accurate mortality estimations and understanding the role of GH therapy.