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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...

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Related Experiment Video

Updated: Jul 8, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Non-IBD and noninfectious colitis.

Ole Haagen Nielsen1, Ben Vainer, Jørgen Rask-Madsen

  • 1Department of Medical Gastroenterology C, Herlev Hospital, University of Copenhagen, Denmark. ohn@dadlnet.dk

Nature Clinical Practice. Gastroenterology & Hepatology
|January 5, 2008
PubMed
Summary
This summary is machine-generated.

This review details rare colitis types beyond IBD, covering microscopic, ischemic, and radiation colitis. It offers diagnostic and therapeutic guidance for these uncommon conditions.

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Area of Science:

  • Gastroenterology
  • Pathology
  • Epidemiology

Background:

  • Colitis encompasses diverse etiologies and pathogenic mechanisms.
  • Non-inflammatory bowel disease (IBD) colitis forms are often rare and recently characterized.
  • Limited epidemiologic data and controlled trial evidence exist for these uncommon conditions.

Purpose of the Study:

  • To provide a comprehensive overview of rare, noninfectious, non-IBD colitis.
  • To detail the pathophysiology, epidemiology, histopathology, and clinical features of specific colitis types.
  • To offer practical diagnostic and therapeutic guidelines where available.

Main Methods:

  • Literature review of noninfectious and non-IBD colitis.
  • Synthesis of information on pathophysiology, epidemiology, histopathology, and clinical characteristics.
  • Identification and summarization of diagnostic and therapeutic approaches.

Main Results:

  • Overview of microscopic colitis, Behçet's syndrome, diversion colitis, diverticular colitis, eosinophilic colitis, ischemic colitis, and radiation colitis.
  • Characterization of these conditions as primary or secondary to other diseases.
  • Highlights the scarcity of epidemiologic and clinical trial data.

Conclusions:

  • Rare colitis forms require specific diagnostic and management strategies.
  • Further research is needed to improve understanding and treatment of these uncommon conditions.
  • This review serves as a practical guide for clinicians encountering these colitis types.