Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Antianginal Drugs: Nitrates and β-Blockers01:16

Antianginal Drugs: Nitrates and β-Blockers

In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates,  such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow. Administered...
Routes of Drug Administration: Parenteral01:25

Routes of Drug Administration: Parenteral

The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
IV Infusion to Oral Dosing: Conversion Methods01:28

IV Infusion to Oral Dosing: Conversion Methods

The development of extended-release formulations has facilitated the transition from intravenous to oral medication, offering a more convenient and patient-friendly approach to drug administration. This transition, however, requires careful management to ensure that therapeutic drug levels are maintained, preserving efficacy and avoiding adverse effects. Understanding pharmacokinetic principles and dosage calculations is critical during this process.Pharmacokinetics of the...
Non-Oral Extravascular Drug Absorption Routes01:15

Non-Oral Extravascular Drug Absorption Routes

Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more effectively...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Two books printed in Strasburg during the 16th century present in the inventory of the Paris College of Pharmacy Library].

Revue d'histoire de la pharmacie·2018
Same author

[Nicolas Lemery, a pluridisciplinary Scientist].

Revue d'histoire de la pharmacie·2018
Same author

[Christophle Glaser, one of Lemery’s].

Revue d'histoire de la pharmacie·2018
Same author

[Pierre Pomet’s opinion on Lemery revealed by the project of a second edition of his General History of Drugs, in 1699 ].

Revue d'histoire de la pharmacie·2018
Same author

[Greek science in the centre of the Dialogue between Orient and Occident ].

Revue d'histoire de la pharmacie·2018
Same author

The copy of the Essays of Jean Rey, used by Bayen and Gobet, at the BIU Sante, pole Pharmacie.

Revue d'histoire de la pharmacie·2018

Related Experiment Video

Updated: Jul 8, 2026

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
13:38

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Published on: January 18, 2017

[From the willow to aspirin].

Olivier Lafont1

  • 1Faculté de médecine et de pharmacie de Rouen, 22 boulevard Gambetta, 76183 Rouen 1.

Revue D'Histoire De La Pharmacie
|January 8, 2008
PubMed
Summary

Willow bark

Area of Science:

  • History of Medicine
  • Organic Chemistry
  • Pharmacology

Background:

  • Ancient civilizations utilized willow bark for medicinal purposes.
  • Edward Stone rediscovered willow's therapeutic properties in the 18th century.
  • Key chemical compounds were isolated and synthesized, paving the way for modern pharmaceuticals.

Observation:

  • Salicin was isolated from willow bark in 1829.
  • Salicylic acid was synthesized from salicin and later from sodium phenate.
  • Acetylsalicylic acid was first synthesized in 1853, with its structure later elucidated.

Findings:

  • The development of acetylsalicylic acid (Aspirin) by Bayer Laboratories revolutionized pain relief.
  • John Vane's 1971 research revealed that aspirin-like drugs inhibit prostaglandin synthesis.

More Related Videos

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
09:37

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Published on: August 1, 2018

Related Experiment Videos

Last Updated: Jul 8, 2026

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
13:38

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Published on: January 18, 2017

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
09:37

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Published on: August 1, 2018

  • This discovery provided a molecular mechanism for aspirin's anti-inflammatory and analgesic effects.

    • Implications:

    • The historical progression from natural remedies to synthetic drugs highlights pharmaceutical innovation.
    • Understanding the mechanism of action of aspirin has broader implications for inflammation and pain research.
    • The journey of aspirin underscores the importance of chemical synthesis and structural elucidation in drug development.