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Modulation of apoptosis to reverse chemoresistance

Gil Mor1, Michele K Montagna, Ayesha B Alvero

  • 1Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA.

Methods in Molecular Biology (Clifton, N.J.)
|January 8, 2008
PubMed

Insights

Cancer cells disrupt natural cell death (apoptosis) to grow. This chapter explores apoptosis in ovarian cancer and phenoxodiol

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Neoplastic transformation involves interference with innate apoptotic activity.
  • Apoptosis plays a crucial role in tumor formation and progression.
  • Modulating apoptosis is a potential cancer treatment strategy.

Purpose of the Study:

  • To discuss the role of apoptosis in ovarian cancer.
  • To examine phenoxodiol as a model for apoptosis regulation.
  • To evaluate phenoxodiol's potential as a chemosensitizer for chemoresistant ovarian cancer.

Main Methods:

  • Literature review on apoptosis in ovarian cancer.
  • Analysis of phenoxodiol's mechanism of action.
  • Discussion of preclinical and clinical data regarding phenoxodiol.

Main Results:

  • Apoptosis interference is a key feature of ovarian cancer.
  • Phenoxodiol demonstrates potential in regulating apoptotic pathways.
  • Phenoxodiol may enhance chemosensitivity in resistant ovarian cancer cells.

Conclusions:

  • Targeting apoptosis is a promising avenue for ovarian cancer therapy.
  • Phenoxodiol represents a potential therapeutic agent for chemoresistant ovarian cancer.
  • Further research into phenoxodiol's role as a chemosensitizer is warranted.

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