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Peripheral Nervous System: Ganglia and Nerves

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Related Experiment Video

Updated: Jul 8, 2026

A Quantitative Cell Migration Assay for Murine Enteric Neural Progenitors

A Quantitative Cell Migration Assay for Murine Enteric Neural Progenitors

Published on: September 18, 2013

CNS-derived glia ensheath peripheral nerves and mediate motor root development.

Sarah Kucenas¹, Norio Takada, Hae-Chul Park

¹Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA.

Nature Neuroscience

|January 8, 2008

Summary

Newly discovered CNS-born glia form the perineurium, acting as a crucial barrier and guide for motor axon development. These perineurial glia also interact with Schwann cells for proper nerve ensheathment.

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Purification of Fibroblasts and Schwann Cells from Sensory and Motor Nerves in Vitro

Purification of Fibroblasts and Schwann Cells from Sensory and Motor Nerves in Vitro

Published on: May 20, 2020

Area of Science:

Neuroscience
Developmental Biology
Cell Biology

Background:

Motor function relies on spinal cord motor axons and Schwann cell myelination.
The perineurium's origin and role in motor nerve formation are poorly understood.
Perineurial cells form a protective barrier around motor nerves.

Purpose of the Study:

To investigate the origin and function of perineurial cells in motor nerve development.
To elucidate the role of perineurial glia in motor axon guidance and nerve ensheathment.

Main Methods:

Time-lapse imaging in zebrafish embryos.
Analysis of motor neuron migration and axonal projections.
Investigation of cell-cell signaling between glia and Schwann cells.

Main Results:

Perineurial cells originate as ventral spinal cord glia and migrate peripherally.
Absence of perineurial glia leads to aberrant motor neuron migration and axonal projections.
Reciprocal signaling between perineurial glia and Schwann cells is essential for nerve ensheathment.

Conclusions:

Perineurial glia are a novel class of CNS-born cells critical for motor nerve development.
These glia provide essential barrier and guidance functions at motor axon exit points.
Perineurial glia and Schwann cells engage in reciprocal signaling for proper nerve formation.