Related Experiment Video
Updated: Jul 8, 2026

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
Published on: January 27, 2014
Short-term clinical evaluation of four desensitizing agents
Adeyemi Oluniyi Olusile1, Cornelius Tokunbo Bamise, Adeleke O Oginni
1Department of Restorative Dentistry of Faculty of Dentistry, College of Health Sciences at Obafemi Awolowo University in Ile-Ife, Nigeria. aolusile@oauife.edu.ng
Four topical agents provided significant short-term relief for dentin hypersensitivity within 24 hours. Gluma showed the best 24-hour efficacy, while iontophoresis demonstrated sustained relief at seven days.
Area of Science:
- Dentistry
- Dental Materials Science
Background:
- Dentin hypersensitivity is a common clinical complaint.
- Effective short-term relief is crucial for patient comfort.
Purpose of the Study:
- To compare the efficacy of four topical desensitizing agents for dentin hypersensitivity.
Main Methods:
- 116 hypersensitive teeth were treated with Duraphat, 2% fluoride iontophoresis, copal varnish (CV), or Gluma Comfort Bond Plus Desensitizer.
- Pain scores were assessed using a visual analogue scale at baseline, 24 hours, and 7 days post-treatment.
Main Results:
- All agents significantly reduced pain within 24 hours (p<0.05).
- Gluma showed the greatest reduction at 24 hours.
- Iontophoresis and Gluma demonstrated statistically significant reductions at seven days.
Conclusions:
- All tested agents offer effective short-term relief for dentin hypersensitivity.
- Gluma and iontophoresis show promise for sustained desensitization.
- Further long-term studies are warranted.
Related Concept Videos
Desensitization and Tachyphylaxis
Several...
Depolarizing Blockers: Pharmocokinetics
Local Anesthetics: Differential Sensitivity of Nerve Fibers
Transdermal Drug Delivery Systems
Drug Toxicity: Allergic Reactions
GPCR Desensitization
