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Updated: Jul 8, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
Nalidixic acid-resistant Salmonella enterica serotype typhi infection presenting with sub-intestinal obstruction and
Tarig S Al-Khuwaitir1, Amin A Al-Zuhair, Ali G Al-Ghamdi
1Department of Medicine, Division of General Internal Medicine, Riyadh Medical Complex, Ministry of Health, PO Box 3847, 11481 Riyadh, Kingdom of Saudi Arabia. khuwaitir@hotmail.com
Abstract:
Nalidixic acid-resistant Salmonella typhi NARST infections increase minimal inhibitory concentrations of fluoroquinolones, due to chromosomal mutations in the gene encoding DNA gyrase, and can lead to a delayed treatment response. This in turn alters the course of the disease allowing for a protracted period of illness and the occurrence of complications. In this case report, we present a patient from the Indian sub-continent, who was diagnosed with NARST complicated by sub-intestinal obstruction, her diagnosis, treatment, and subsequent recovery.
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