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Related Experiment Video

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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

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Published on: December 15, 2011

Autoantibodies in celiac disease.

Armin Alaedini¹, Peter H R Green

¹Department of Neurology and Neuroscience, Cornell University, New York, NY 10021, USA. ara2004@med.cornell.edu

|January 8, 2008

Summary

Autoantibodies like anti-transglutaminase 2 (TG2) are key indicators in celiac disease diagnosis and monitoring. This review explores their role in celiac disease pathogenesis and potential triggers.

Area of Science:

Immunology
Gastroenterology
Autoimmune Diseases

Background:

Autoantibody production signifies immune system breakdown in autoimmune disorders.
Celiac disease is an autoimmune enteropathy with extra-intestinal manifestations.
Anti-transglutaminase 2 (TG2) autoantibodies are specific markers for celiac disease.

Purpose of the Study:

To review the presence and diagnostic value of anti-TG2 and other autoantibodies in celiac disease.
To discuss the potential role of these autoantibodies in celiac disease pathogenesis.
To examine hypotheses regarding the triggers for autoantibody release in celiac disease.

Main Methods:

Literature review of studies on autoantibodies in celiac disease.
Analysis of diagnostic utility of anti-TG2 antibodies.

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Exploration of research on other autoantigens implicated in celiac disease.

Main Results:

Anti-TG2 antibodies closely correlate with the acute phase of celiac disease, aiding diagnosis and follow-up.
Reactivity to other autoantigens (TG3, actin, ganglioside, collagen, calreticulin, zonulin) is reported in celiac disease.
The clinical significance of antibodies to these other autoantigens is largely unknown but may link to specific manifestations.

Conclusions:

Anti-TG2 autoantibodies are crucial for celiac disease diagnosis and management.
Further research is needed to understand the clinical significance and pathogenic role of other celiac disease-associated autoantibodies.
Investigating triggers for autoantibody release is essential for a comprehensive understanding of celiac disease.