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Related Experiment Video

Updated: Jul 8, 2026

In Vivo Imaging of Reactive Oxygen Species in a Murine Wound Model

In Vivo Imaging of Reactive Oxygen Species in a Murine Wound Model

Published on: November 17, 2018

Redox-based therapeutics for lung diseases.

Yuma Hoshino¹, Michiaki Mishima

¹Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto, Japan. yuma@kuhp.kyoto-u.ac.jp

Antioxidants & Redox Signaling

|January 8, 2008

Summary

Oxidative stress contributes to many lung diseases due to diverse sources and factors. Targeting disease-specific pathways and using biomarkers offers promising therapeutic and management strategies for lung disorders.

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Use of Electron Paramagnetic Resonance in Biological Samples at Ambient Temperature and 77 K

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Last Updated: Jul 8, 2026

In Vivo Imaging of Reactive Oxygen Species in a Murine Wound Model

In Vivo Imaging of Reactive Oxygen Species in a Murine Wound Model

Published on: November 17, 2018

Use of Electron Paramagnetic Resonance in Biological Samples at Ambient Temperature and 77 K

Use of Electron Paramagnetic Resonance in Biological Samples at Ambient Temperature and 77 K

Published on: January 11, 2019

Area of Science:

Pulmonary Medicine
Biochemistry
Pathophysiology

Background:

Oxidative stress is a common etiological factor in various lung diseases, stemming from diverse sources and contributing factors.
The uniform involvement of oxidative stress across different lung pathologies necessitates a deeper understanding of its disease-specific roles.
Biomarkers of oxidative stress, such as exhaled nitric oxide for asthma, are crucial for disease management and monitoring.

Discussion:

Current antioxidant therapies like N-acetylcysteine have shown limited clinical success in lung disorders.
Improving clinical outcomes may involve combination therapies or refined patient selection strategies for antioxidant treatments.
Noninvasive techniques, including exhaled breath condensate analysis, are enabling the evaluation of novel oxidative stress and antioxidant biomarkers.

Key Insights:

Characterizing the disease-specific involvement of oxidative stress is essential for developing targeted therapeutics.
Oxidative stress biomarkers provide valuable tools for the clinical management of lung diseases.
Identifying and modulating disease-specific redox-sensitive signaling pathways presents a promising therapeutic avenue.

Outlook:

Novel antioxidant drugs are under investigation to improve treatment efficacy.
Molecular targeted therapies focusing on redox-sensitive pathways offer an alternative to broad antioxidant approaches.
Regulating disease-specific pathways may lead to more efficient and less toxic therapeutic interventions compared to targeting universal pathways.