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Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents

Hilary P Beck1, Todd Kohn, Steven Rubenstein

  • 1Chemistry Research & Discovery, Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA. hbeck@amgen.com

Bioorganic & Medicinal Chemistry Letters
|January 8, 2008
PubMed

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...