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Related Concept Videos

Apoptosis01:30

Apoptosis

Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size reduction of the tissue.
Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized by phagocytes.
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
Cellular Injury V: Apoptosis and Autophagy01:22

Cellular Injury V: Apoptosis and Autophagy

Cells respond to damage and stress through highly coordinated processes that decide whether they survive or undergo controlled self-destruction. Two major pathways involved in this regulation are apoptosis, a type of programmed cell death, and autophagy, a survival mechanism that helps cells adapt to adverse conditions.ApoptosisApoptosis removes aged or injured cells to maintain tissue balance. During this process, the cell shrinks, chromatin condenses and fragments, and membrane-bound...

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Related Experiment Video

Updated: Jul 8, 2026

Generation of Lymphocytic Microparticles and Detection of their Proapoptotic Effect on Airway Epithelial Cells
09:26

Generation of Lymphocytic Microparticles and Detection of their Proapoptotic Effect on Airway Epithelial Cells

Published on: February 20, 2015

Apoptosis in the lung: induction, clearance and detection.

P M Henson1, R M Tuder

  • 1Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA. hensonp@njc.org.

American Journal of Physiology. Lung Cellular and Molecular Physiology
|January 8, 2008
PubMed
Summary

Programmed cell death, or apoptosis, plays a key role in lung diseases. Detecting apoptotic cells in the lungs and understanding their clearance is crucial for lung pathophysiology.

More Related Videos

Detection and Isolation of Apoptotic Bodies to High Purity
12:17

Detection and Isolation of Apoptotic Bodies to High Purity

Published on: August 12, 2018

Related Experiment Videos

Last Updated: Jul 8, 2026

Generation of Lymphocytic Microparticles and Detection of their Proapoptotic Effect on Airway Epithelial Cells
09:26

Generation of Lymphocytic Microparticles and Detection of their Proapoptotic Effect on Airway Epithelial Cells

Published on: February 20, 2015

Detection and Isolation of Apoptotic Bodies to High Purity
12:17

Detection and Isolation of Apoptotic Bodies to High Purity

Published on: August 12, 2018

Area of Science:

  • Pulmonary Medicine
  • Cell Biology
  • Pathophysiology

Background:

  • Apoptosis and programmed cell death are significant factors in lung pathophysiology.
  • Detecting apoptotic cells in lung tissue is an area of research interest.
  • The dynamic balance between apoptosis induction and clearance is critical in lung health.

Purpose of the Study:

  • To review the implications of finding apoptotic cells in the lung.
  • To discuss methods for detecting apoptotic cells in the lung.
  • To explore the consequences of apoptotic cell recognition by other lung cells.

Main Methods:

  • Literature review of apoptosis and programmed cell death in lung pathophysiology.
  • Discussion of methods for detecting apoptotic cells.
  • Analysis of the implications of apoptotic cell clearance and recognition.

Main Results:

  • Abnormalities in apoptotic cell clearance may explain their presence in the lung.
  • Recognition of apoptotic cells by lung cells influences inflammation, immunity, and repair.
  • Local responses to dying cells have consequences beyond cell death itself.

Conclusions:

  • Understanding apoptotic cell dynamics in the lung is vital for comprehending lung diseases.
  • Impaired clearance of apoptotic cells is a potential factor in lung pathophysiology.
  • The interaction between dying cells and other lung cells impacts tissue homeostasis and disease progression.