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Updated: Jul 8, 2026

Analysis of Cell Cycle Position in Mammalian Cells
Published on: January 21, 2012
CD22 regulates time course of both B cell division and antibody response
Taishi Onodera1, Jonathan C Poe, Thomas F Tedder
1Laboratory of Immunology, School of Biomedical Science, Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Japan.
Abstract:
Because pathogens induce infectious symptoms in a time-dependent manner, a rapid immune response is beneficial for defending hosts from pathogens, especially those inducing acute infectious diseases. However, it is largely unknown how the time course of immune responses is regulated. In this study, we demonstrate that B cells deficient in the inhibitory coreceptor CD22 undergo accelerated cell division after Ag stimulation, resulting in rapid generation of plasma cells and Ab production. This finding indicates that CD22 regulates the time course of B cell responses and suggests that CD22 is a good target to shorten the time required for Ab production, thereby augmenting host defense against acute infectious diseases as "universal vaccination."
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