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Updated: Jul 8, 2026

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays
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Published on: June 9, 2015

T cell development from kit-negative progenitors in the Foxn1Delta/Delta mutant thymus

Shiyun Xiao1, Dong-ming Su, Nancy R Manley

  • 1Department of Genetics, Coverdell Center, University of Georgia, Athens, GA 30602, USA.

Journal of Immunology (Baltimore, Md. : 1950)
|January 8, 2008
PubMed
Summary

The Foxn1Delta mutation impairs T cell development by affecting thymic epithelial cells, leading to atypical T cell progenitors and increased B cell development. This study clarifies the developmental block in T cell precursors within the mutant thymus.

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