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Related Concept Videos

Prosopagnosia01:24

Prosopagnosia

Prosopagnosia, also known as face blindness, is the inability to recognize faces. In severe cases, individuals with prosopagnosia may not recognize close family members, including parents and spouses, by their faces. For instance, someone with prosopagnosia might walk past their child in a crowd, only realizing their mistake upon noticing their child's distinctive backpack or favorite jacket. Prosopagnosia specifically impairs facial recognition, while the recognition of other objects or...
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...

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Related Experiment Video

Updated: Jul 8, 2026

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection
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Published on: April 12, 2024

Holoprosencephaly--a case report.

Hosenera Begum1, Kaustav Nayek

  • 1Department of Paediatrics, Calcutta Medical College, Kolkata.

Journal of the Indian Medical Association
|January 9, 2008
PubMed
Summary

A newborn presented with delayed breathing and a large monoventricle, indicating alobar holoprosencephaly with hydrocephalus. This rare congenital brain malformation requires prompt diagnosis and management.

Area of Science:

  • Neonatal neurology
  • Developmental neuroscience
  • Pediatric radiology

Background:

  • Delayed respiration in newborns can signify critical underlying conditions.
  • Holoprosencephaly is a spectrum of brain malformations resulting from incomplete forebrain division.

Observation:

  • A term newborn exhibited delayed respiration and an unusually large head circumference (40.5 cm).
  • Radiological imaging revealed significant sutural separation on skull X-ray.
  • Cranial CT scan demonstrated a large monoventricle occupying most of the brain cavity.

Findings:

  • The observed features are characteristic of alobar holoprosencephaly.
  • Concurrent hydrocephalus was identified as a significant complication.
  • The infant was managed for birth asphyxia.

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Implications:

  • Early identification of alobar holoprosencephaly with hydrocephalus is crucial for appropriate neonatal care.
  • This case highlights the importance of advanced neuroimaging in diagnosing complex congenital brain anomalies.
  • Understanding such malformations aids in counseling families and planning potential interventions.