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Updated: Jul 8, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
Genetic imbalance and human papillomavirus states in vulvar squamous cell carcinomas
O Yangling1, Z Shulang, C Rongli
1Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Purpose Of Investigation:
Vulvar squamous cell carcinoma (VSCC) is a disease of significant clinical importance, which arises in the presence or absence of human papillomavirus (HPV).
Methods:
We used comparative genomic hybridization (CGH) to document non-random chromosomal gains and losses with HPV positive and negative VSCCs.
Results:
Gains of 3q and 12q were significantly more common in HPV-positive cancers compared to HPV-negative cancers where chromosome 8q was more commonly gained in HPV-negative compared to HPV-positive cancer chromosomes and, 4p and 3p were lost in both categories of VSCCs.
Conclusions:
The data indicate that one or more oncogenes important in the development and progression of HPV-induced carcinomas are located on 3q and 12q.
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