Related Experiment Videos
[Adverse side effects of amalgam? An interdisciplinary study].
1Poliklinik für Zahnerhaltung und Parodontologie der Universität Erlangen-Nürnberg.
Deutsche Zahnarztliche Zeitschrift
|August 1, 1991
Summary
This study found mercury levels in urine correlate with amalgam fillings but remain below toxic limits. No significant immunological or allergological issues were found to reject amalgam as a dental filling material.
Area of Science:
- Environmental Health
- Toxicology
- Immunology
Context:
- Investigated patient-reported symptoms linked to dental amalgam fillings.
- Utilized an interdisciplinary approach over 2.5 years with 50 participants.
Purpose:
- To assess mercury (Hg) levels in urine and immunological parameters in patients with dental amalgam fillings.
- To determine if measured Hg concentrations and immunological findings warrant rejection of amalgam as a dental filling material.
Summary:
- Urine mercury concentration correlates with the number of amalgam fillings, both before and after DMPS (2,3-Dimercapto-1-propane-sulfonic-acid) administration.
- Mobilized mercury levels were significantly below toxicologically critical limits (max 66.4 µg Hg/24h urine).
- Most patients showed normal immunological values; only 3 exceeded standard ranges. Psychiatric and psychological issues were prevalent in 65% of patients, but not directly linked to amalgam.
- No current evidence supports rejecting amalgam based on Hg levels, immunological, or allergological findings.
Impact:
- Provides data on mercury exposure and health effects associated with dental amalgam.
- Informs clinical decisions regarding the safety and use of amalgam fillings.
- Highlights the prevalence of psychological conditions in patients seeking evaluation for amalgam-related symptoms.