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Updated: Jul 8, 2026

Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications
Published on: December 8, 2016
The use of marrow-derived stem cells to accelerate healing in chronic wounds
Lee C Rogers1, Nicholas J Bevilacqua, David G Armstrong
1Amputation Prevention Center, Broadlawns Medical Center, Des Moines, IA, USA.
Abstract:
Adult bone marrow-derived stem cells may aid the healing of chronic lower extremity wounds by transplanting a population of progenitor cells locally into the wound. We present results from three cases in which bone marrow aspirate containing marrow-derived cells was applied/injected locally into complex lower extremity chronic wounds of differing aetiologies. Our case series suggest that bone marrow aspirate, applied topically and injected into the wound periphery, may be a useful and potentially safe adjunct to wound simplification and ultimate closure.
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