Normal values for the satiety drinking test in healthy children between 5 and 15 years
1Division of Pediatrics, Department of Gastroenterology, University Hospitals Leuven, Leuven, Belgium. ilse.hoffman@uzleuven.be
Neurogastroenterology and Motility
|January 9, 2008
Summary
This study established normal values for a non-invasive satiety drinking test in children aged 5-15. The test
Area of Science:
- Pediatric Gastroenterology
- Digestive Physiology
Background:
- Functional dyspepsia (FD) diagnosis in children lacks established normative data for gastric accommodation tests.
- Previous studies focused on adult and adolescent populations for satiety drinking tests.
Purpose of the Study:
- To establish normal values for a non-invasive satiety drinking test in young children (ages 5-15).
- To investigate the influence of demographic factors on test results in children.
Main Methods:
- 59 healthy children (ages 5-16) consumed a liquid nutrient meal at a controlled rate.
- Satiety was scored on a 0-5 scale until maximum satiety was reached.
- Age-dependent normal ranges were determined and correlated with demographic data.
Main Results:
- The satiety drinking test was feasible in children aged 5-15.
- The endpoint volume (mean ± SEM) was 360 ± 23 mL (540 ± 34 kcal).
- Ingested volume significantly correlated with age (Spearman r = 0.28, P = 0.03) but not gender, weight, height, or BMI.
Conclusions:
- Normal values for the satiety drinking test in children aged 5-16 were established and increase with age.
- This non-invasive test is now validated for assessing pediatric functional dyspepsia and eating disorders.
Related Concept Videos
Serum Studies: Renal Function Tests
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
Regulation of Water Intake
Osmolality refers to the number of solute particles per kilogram of solvent in a solution. Plasma osmolality specifically indicates the total number of solute particles per kilogram of water in blood plasma. This value reflects the body's hydration status and is tightly regulated through mechanisms controlling water intake and output. While water consumption is a conscious decision, the body has intrinsic regulatory systems to maintain fluid balance. Dehydration, a state of water deficit...
Bioavailability Study Design: Healthy Subjects Versus Patients
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
Primary Motives: Hunger and Thirst
Hunger and thirst are fundamental physiological drives crucial for maintaining homeostasis and ensuring the survival of both humans and animals. These drives are regulated through complex interactions between the brain, hormones, and sensory receptors.
Hunger arises when the brain detects changes in the body's nutrient levels, including glucose, lipids, amino acids, and hormones such as ghrelin and leptin. The hypothalamus plays a central role in hunger regulation. The lateral hypothalamus acts...
Hunger arises when the brain detects changes in the body's nutrient levels, including glucose, lipids, amino acids, and hormones such as ghrelin and leptin. The hypothalamus plays a central role in hunger regulation. The lateral hypothalamus acts...
Pharmacokinetics in Pediatric Patients: Drug Metabolism
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...


