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Updated: Jul 8, 2026

In Vivo Assessment of Alveolar Macrophage Efferocytosis Following Ozone Exposure
Published on: October 22, 2019
Apoptosis, airway inflammation and anti-asthma therapy: from immunobiology to clinical application
Fabrizio Spinozzi1, Diletta de Benedictis, F M de Benedictis
1Department of Clinical and Experimental Medicine, University of Perugia, Italy.
Abstract:
T lymphocyte apoptosis is essential for maintaining immune system homeostasis. Experimental evidence suggests apoptosis control mechanisms may be impaired in inflammatory conditions, particularly airway Th2-type allergic diseases. This review briefly examines the mucosal immune system homeostasis and common apoptotic pathways and discusses impaired apoptosis, allergy, airway inflammation, remodelling and fibrosis. Finally, the paper presents an update on pharmacological targeting of apoptosis to control airway inflammation in patients with allergic asthma.
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