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Vertical hepatitis C virus transmission is not related to mother-child class-1 HLA concordance

C Azzari1, G Indolfi, L Betti

  • 1Department of Paediatrics, University of Florence, Anna Meyer Children's Hospital, Florence, Italy. maurizio.demartino@unifi.it

International Journal of Immunopathology and Pharmacology
|January 9, 2008
PubMed

Mother-child human leukocyte antigen (HLA)diversity is protective for vertical transmission of some viruses. The aim of this study is to evaluate the role of mother-child HLA diversity on hepatitis C virus (HCV) vertical transmission. Forty consecutive HCV infected and 46 consecutive control uninfected children born to HCV-RNA positive mothers were evaluated for HLA class-1 type concordance with their mothers. No significant difference in the degree of HLA concordance was found between HCV infected and uninfected children both when A, B, C (p=0.30) and when only A and B alleles were evaluated (p=0.59). Mother-infant HLA concordance does not affect HCV vertical transmission.

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