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MEGF10 association with schizophrenia.

Xiangning Chen1, Xu Wang, Qi Chen

  • 1Department of Psychiatry, Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA. xchen@vcu.edu

Biological Psychiatry
|January 9, 2008
PubMed
Summary
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The MEGF10 gene shows a significant association with schizophrenia risk. Specific genetic variations and higher MEGF10 expression in brain tissue are linked to increased disease susceptibility.

Area of Science:

  • Neurogenetics
  • Psychiatric Disorders

Background:

  • The 5q21-31 chromosomal region is linked to schizophrenia risk.
  • MEGF10 gene identified through prior fine-mapping studies in this region.
  • This study focuses on independent replication and expression analysis of MEGF10.

Purpose of the Study:

  • To validate the association of the MEGF10 gene with schizophrenia.
  • To investigate the expression levels of MEGF10 in schizophrenia patients.
  • To determine the role of specific MEGF10 genetic variants in disease risk.

Main Methods:

  • Case-control association study using 8 single nucleotide polymorphisms (SNPs) in the MEGF10 gene within the Irish Case-Control Study of Schizophrenia (ICCSS) sample.
  • Comparison of MEGF10 gene expression in postmortem brain cDNA libraries from schizophrenia patients and healthy controls.

Related Experiment Videos

Main Results:

  • Replication of disease associations with MEGF10 risk alleles and haplotypes found in prior studies.
  • Significant overrepresentation of the major allele (A) at rs27388 in schizophrenia cases (p = .0169).
  • Elevated MEGF10 expression observed in the brains of schizophrenia patients (p = .015), with higher expression in patients carrying the 1/1 genotype at rs27388 (p = .0008).

Conclusions:

  • Combined genetic association and gene expression data strongly implicate MEGF10 in schizophrenia.
  • The major allele and 1/1 genotype at rs27388 are associated with increased schizophrenia risk.
  • MEGF10 represents a potential genetic risk factor for schizophrenia.