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Allergic interstitial nephritis possibly related to sunitinib use
1Scott & White Memorial Hospital and Clinic, Texas A&M College of Health Sciences Center, Temple, Texas 76508, USA. anandkhurana@yahoo.com
The American Journal of Geriatric Pharmacotherapy
|January 9, 2008
Summary
Sunitinib, used for renal cell carcinoma, may cause allergic interstitial nephritis. Early monitoring of kidney function and white blood cells after starting sunitinib is recommended to prevent damage.
Area of Science:
- Nephrology
- Oncology
- Pharmacology
Background:
- Sunitinib is an oral multitargeted inhibitor for renal cell carcinoma treatment.
- This case highlights a potential adverse effect of sunitinib therapy.
Observation:
- A patient developed kidney dysfunction, proteinuria, eosinophilia, and eosinophiluria during sunitinib treatment.
- These symptoms worsened with continued sunitinib and resolved upon discontinuation.
- Re-challenge with a similar drug, sorafenib, caused similar adverse effects.
Findings:
- The patient's presentation and Naranjo scale score indicated a probable link between sunitinib and allergic interstitial nephritis.
- Renal biopsy was deferred due to patient's condition and solitary kidney.
- The adverse event may represent a class effect among similar targeted therapies.
Implications:
- Nephrologists and oncologists should consider allergic interstitial nephritis as a potential sunitinib adverse effect.
- Monitoring serum creatinine and white cell count within two weeks of starting sunitinib is advised for early detection.
- Proactive monitoring can help prevent significant renal damage from this drug-induced condition.
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