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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
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Journal of Controlled Release : Official Journal of the Controlled Release Society
|January 9, 2008
PubMed
Summary

Floating Kollidon SR matrix tablets effectively delayed Propranolol HCl release for 24 hours, demonstrating Fickian diffusion kinetics. High polymer ratios enhanced tablet floating strength and characteristics.

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Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Materials Science

Background:

  • Development of sustained-release drug delivery systems is crucial for improving therapeutic efficacy and patient compliance.
  • Floating matrix tablets offer prolonged gastric residence time, enhancing drug absorption.
  • Propranolol Hydrochloride (HCl) is a widely used beta-blocker requiring controlled release formulations.

Purpose of the Study:

  • To develop and characterize floating Kollidon SR matrix tablets for Propranolol HCl.
  • To evaluate drug release kinetics, floating strength, and swelling behavior.
  • To explore the utility of benchtop MRI for non-invasive analysis of water diffusion and swelling.

Main Methods:

  • Formulation of Propranolol HCl loaded Kollidon SR matrix tablets.
  • In vitro drug release studies using the Korsmeyer-Peppas model.
  • Assessment of tablet floating time and floating strength.
  • Analysis of tablet swelling characteristics using the Therien-Aubin equation.
  • Application of benchtop magnetic resonance imaging (MRI) for water diffusion and swelling studies.

Main Results:

  • Kollidon SR effectively delayed Propranolol HCl release, following Fickian diffusion kinetics.
  • Tablets exhibited immediate and sustained floating for 24 hours.
  • Floating strength correlated positively with Kollidon SR concentration, with higher polymer/drug ratios yielding better results.
  • Polymer content had a marginal effect on swelling characteristics.
  • Benchtop MRI provided non-invasive, continuous monitoring of water diffusion and swelling.

Conclusions:

  • Floating Kollidon SR matrix tablets are a viable system for sustained release of Propranolol HCl.
  • The formulation demonstrates excellent floating stability and tunable release profiles.
  • Benchtop MRI is a promising tool for characterizing swelling and water diffusion in such systems.
  • Optimizing the polymer/drug ratio is key to maximizing floating performance.