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Updated: Jul 8, 2026

Methods to Study Mrp4-containing Macromolecular Complexes in the Regulation of Fibroblast Migration
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Published on: May 19, 2016

Alternate cyclin D1 mRNA splicing modulates p27KIP1 binding and cell migration

Zhiping Li1, Chenguang Wang, Xuanmao Jiao

  • 1Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

The Journal of Biological Chemistry
|January 9, 2008
PubMed
Summary

Altered RNA splicing of the cyclin D1 gene creates variant cyclin D1b. Unlike cyclin D1a, cyclin D1b does not affect cellular migration by stabilizing p27 KIP1 or inhibiting RhoA signaling.

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