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Published on: April 19, 2013
Factor V Leiden mutation and type 1 diabetes mellitus
Asli Nar Demirer1, Mehmet Alikasifoglu, Ergul Tuncbilek
1Department of Endocrinology and Metabolism, Baskent University Medical School, Ankara, Turkey. aslinar@hotmail.com
Summary
Factor V Leiden mutation and activated protein C resistance are not linked to type 1 diabetes or its complications. These factors do not appear to significantly influence thrombosis risk in diabetic patients.
Area of Science:
- Medical research
- Hematology
- Endocrinology
Background:
- Diabetes mellitus is associated with increased arterial thrombosis risk.
- Activated protein C resistance, often due to factor V Leiden mutation, is a common cause of venous thrombosis.
- Limited data exists on factor V Leiden mutation prevalence in type 1 diabetes.
Purpose of the Study:
- To investigate the association between activated protein C sensitivity ratio, factor V Leiden mutation, and type 1 diabetes.
- To explore potential links with metabolic control, lipid profiles, and diabetic complications.
- To clarify the role of these thrombotic factors in type 1 diabetes.
Main Methods:
- Study included 47 healthy individuals and 48 type 1 diabetic patients.
- Activated protein C sensitivity ratio was measured using an activated partial thromboplastin time-based assay.
- Factor V Leiden mutation presence was identified via PCR amplification.
Main Results:
- No significant differences in mean normalized activated protein C sensitivity ratio or heterozygous factor V Leiden mutation prevalence were observed between groups.
- Neither activated protein C sensitivity ratio nor factor V Leiden mutation showed a link to metabolic control, lipids, or diabetic complications in type 1 diabetes patients.
- No association was found between factor V Leiden mutation, activated protein C sensitivity ratio, type 1 diabetes, metabolic parameters, or complications.
Conclusions:
- Despite increased thrombosis propensity in type 1 diabetes, activated protein C sensitivity ratio and factor V Leiden mutation are not significant determinants.
- These specific genetic and functional markers of thrombophilia do not appear to play a major role in type 1 diabetes-related thrombosis.
- Further research may be needed to identify other contributing factors to the heightened thrombotic risk in type 1 diabetes.
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