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[Cytomegalovirus disease in HIV-1 infected Chilean children]

Anamaría Peña1, Carmen Larrañaga, Vivian Luchsinger

  • 1Hospital Dr. Sótero del Río, Pontificia Universidad Católica de Chile, Santiago, Chile.

Revista Chilena De Infectologia : Organo Oficial De La Sociedad Chilena De Infectologia
|January 9, 2008
PubMed

Insights

Cytomegalovirus (CMV) disease is common in Chilean children with human immunodeficiency virus type 1 (HIV-1), causing significant mortality. Prompt diagnosis and ganciclovir treatment are crucial for better outcomes in these vulnerable patients.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Immunocompromised Hosts

Context:

  • Cytomegalovirus (CMV) is a significant opportunistic infection in children with human immunodeficiency virus type 1 (HIV-1).
  • CMV infection contributes to substantial morbidity and mortality in this population.
  • Chilean HIV-1 infected children represent a cohort with potential vulnerability to CMV disease.

Purpose:

  • To investigate the frequency of Cytomegalovirus (CMV) disease in a prospective cohort of HIV-1 infected children in Chile.
  • To assess the clinical impact and outcomes of CMV disease in this specific pediatric population.
  • To evaluate diagnostic methods and treatment efficacy for CMV disease in HIV-1 infected children.

Summary:

  • Cytomegalovirus (CMV) disease was diagnosed in 12.6% (28/222) of HIV-1 infected children.
  • The majority of cases were severe (CDC Category C and Stage 3), with lung disease being the most frequent manifestation.
  • Shell vial assay was the primary diagnostic tool; all patients received intravenous ganciclovir, with two deaths during the CMV episode.

Impact:

  • CMV disease is a frequent and potentially fatal complication in HIV-1 infected Chilean children.
  • Early detection and prompt treatment with ganciclovir are critical for improving survival rates.
  • This study highlights the importance of vigilant CMV monitoring in pediatric HIV cohorts.
Abstract

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