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Interleukin-6 -174 genotype, periodontal disease and adverse pregnancy outcomes: a pilot study
1Greater Manchester School for Professions Complementary to Dentistry, Salford Primary Care Trust, St James House, Pendleton Way, Salford, UK.
This study was undertaken to investigate whether maternal periodontal disease and variant genotypes of IL-6 gene are associated with adverse pregnancy outcomes. A total of 145 pregnant women were recruited from St Mary's Hospital, Manchester, UK. Bleeding on probing (BOP) and pocket depth indices were recorded on all teeth. Amplification refractory mutation system-polymerase chain reaction was used for -174 IL-6 genotyping. Birth weight was assessed using the individualized birth ratio (IBR) with intrauterine growth restriction (IUGR) defined as an IBR below the fifth percentile. The G/G genotype results in more BOP % sites in Caucasian (P < 0.001) and Afro-Caribbean pregnant women (P = 0.035). In addition, a marginal significant association between the -174 C/C genotype and IUGR was observed (P = 0.06). The -174* C allele was more frequent in women with IUGR than in normal women (63 vs 37%, P = 0.05). Moreover, the combination between the carriage of -174C allele and increased bleeding sites have increased the risk of IUGR (P = 0.006). Future studies, with a larger sample size, are required to better clarify the relationship between the IL-6 gene polymorphism, periodontal disease, and IUGR.
This study was undertaken to investigate whether maternal periodontal disease and variant genotypes of IL-6 gene are associated with adverse pregnancy outcomes. A total of 145 pregnant women were recruited from St Mary's Hospital, Manchester, UK. Bleeding on probing (BOP) and pocket depth indices were recorded on all teeth. Amplification refractory mutation system-polymerase chain reaction was used for -174 IL-6 genotyping. Birth weight was assessed using the individualized birth ratio (IBR) with intrauterine growth restriction (IUGR) defined as an IBR below the fifth percentile. The G/G genotype results in more BOP % sites in Caucasian (P < 0.001) and Afro-Caribbean pregnant women (P = 0.035). In addition, a marginal significant association between the -174 C/C genotype and IUGR was observed (P = 0.06). The -174* C allele was more frequent in women with IUGR than in normal women (63 vs 37%, P = 0.05). Moreover, the combination between the carriage of -174C allele and increased bleeding sites have increased the risk of IUGR (P = 0.006). Future studies, with a larger sample size, are required to better clarify the relationship between the IL-6 gene polymorphism, periodontal disease, and IUGR.
