Breast cyst fluid plasmin activity and its effect on TGF-beta2 activation

Hakan Erbas1, Oya Erten, Mehmet E Irfanoglu

  • 1Department of Biochemistry, Faculty of Medicine, University of Trakya, Edirne, Turkey. herbas@trakya.edu.tr

Cancer Investigation
|January 9, 2008
PubMed

Related Concept Videos

TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...