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Conservative Site-specific Recombination and Phase Variation02:53

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Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
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The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
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Published on: July 13, 2013

Re-examining community based research protocols.

Mary Frances Oneha1, Sheila Beckham

  • 1Waianae Coast Comprehensive Health Center, 86-260 Farrington Hwy, Waianae, HI 96792, USA.

Pacific Health Dialog
|January 10, 2008
PubMed
Summary
This summary is machine-generated.

This study revisits research guidelines for the Waiànae community, focusing on community-based participatory research challenges and data ownership. It aims to improve research practices in indigenous communities.

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Area of Science:

  • Community-based participatory research
  • Indigenous health research
  • Health disparities

Background:

  • The Waiànae community faces significant medical, psychosocial, geographic, and economic adversities, disproportionately affecting its indigenous population.
  • Despite challenges, the community possesses distinct cultural and political strengths and a history of activism.
  • Existing research guidelines for community-based research often originate from academic or professional organizations, not community perspectives.

Purpose of the Study:

  • To re-examine and update research guidelines previously established by the Waianae Coast Comprehensive Health Center.
  • To address ongoing issues impacting research conducted within the Waiànae community.
  • To provide a community-centered perspective on research practices.

Main Methods:

  • Review and re-evaluation of existing research guidelines from the Waianae Coast Comprehensive Health Center.
  • Analysis of challenges and successes in community-based research partnerships.
  • Description of the process for research proposal submission and essential community elements.

Main Results:

  • Identified persistent challenges in accessing the Waiànae community for research.
  • Outlined critical community elements necessary for successful research proposals.
  • Discussed complex issues surrounding data ownership in community-based research.
  • Highlighted challenges encountered in research partnerships.

Conclusions:

  • Revisiting and adapting research guidelines is crucial for ethical and effective research in indigenous communities.
  • Community engagement and collaboration are essential for addressing health disparities.
  • Addressing issues of access, proposal submission, and data ownership strengthens community-researcher partnerships.