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Related Experiment Video

Updated: Jul 8, 2026

Design and Implementation of a Rat Ex Vivo Lung Perfusion Model

Design and Implementation of a Rat Ex Vivo Lung Perfusion Model

Published on: May 26, 2023

Modelling lung and tissue diffusion using a membrane oxygenator circuit.

H Dunningham¹, C Borland, F Bottrill

¹Cambridge Perfusion Services, Papworth Hospital, Papworth Everard, Cambridge, CAMBS, UK.

|January 10, 2008

Summary

This summary is machine-generated.

Researchers developed a simple model lung using a membrane oxygenator circuit. This model consistently achieved normoxia and normocapnia, providing reproducible results for physiological monitoring.

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Area of Science:

Cardiovascular and Respiratory Systems Engineering
Biomedical Device Design
In Vitro Physiological Modeling

Background:

Developing reliable in vitro models for lung function is crucial for research.
Existing models may lack the stability or reproducibility needed for extended physiological studies.

Purpose of the Study:

To design and validate a simple, reproducible model lung system.
To establish reference ranges for blood gas parameters within the model.

Main Methods:

Utilized a membrane oxygenator circuit with two membrane oxygenators.
Primed the circuit with 1-2 liters of equine blood.
Maintained specific blood flow, oxygenator ventilation, and deoxygenator ventilation gas compositions and rates.

Main Results:

Achieved consistent normoxia (PaO2: 81.3 mmHg) and normocapnia (PaCO2: 36.1 mmHg) over several hours.
Demonstrated reproducible oxygen consumption (MO2: 116 ml/min) and carbon dioxide production (MCO2: 169 ml/min).
Observed linear relationships between inspired gas fractions (FiO2, FiCO2) and arterialized blood gas levels (PaO2, PvCO2).

Conclusions:

The designed membrane oxygenator circuit provides a simple and reproducible model lung.
The model is suitable for studying gas exchange and maintaining stable physiological conditions in vitro.
Established reference ranges for blood gas parameters (PaO2, PvO2, PaCO2, PvCO2) and gas transfer (MO2, MCO2) in this equine blood model.