Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complement System01:27

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a membrane...
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Towards sustainable implementation of robotic surgery: an interregional strategic framework from Norway.

Journal of robotic surgery·2026
Same author

Complement activation in patients with post-acute sequelae after SARS-CoV-2 infection.

Frontiers in immunology·2026
Same author

Implantation of a Continuous-Flow Left Ventricular Assist Device During Cardiopulmonary Bypass Is Associated with a Significant and Transient Acute Thromboinflammatory Response.

International journal of molecular sciences·2026
Same author

Distinct Proteomic and Transcriptomic Profiles in T-cells and Monocytes in Patients with Common Variable Immunodeficiency: an Exploratory Study.

Journal of clinical immunology·2026
Same author

"I Want to Spend My Time Living"-Experiences With a Digital Outpatient Service With a Mobile App for Tailored Care Among Adults With Long-Term Health Service Needs: Qualitative Study Using Thematic Analysis.

Journal of medical Internet research·2026
Same author

Validation of shear wave elastography for assessing myocardial fibrosis in patients with end-stage heart failure.

European heart journal. Cardiovascular Imaging·2026

Related Experiment Video

Updated: Jul 8, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
05:25

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft

Published on: September 15, 2023

Off-pump cardiac surgery abolishes complement activation.

Tom N Hoel1, Vibeke Videm, Tom E Mollnes

  • 1Department of Thoracic and Cardiovascular Surgery, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway. tom.nilsen.hoel@rikshospitalet.no

Perfusion
|January 10, 2008
PubMed
Summary

Off-pump coronary artery bypass grafting (CABG) surgery eliminates heart-lung machine-induced complement activation compared to on-pump CABG. While neutrophil and platelet activation were similar, coagulation was more pronounced in the off-pump group.

More Related Videos

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
09:12

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery

Published on: March 27, 2018

A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats
09:54

A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats

Published on: March 23, 2018

Related Experiment Videos

Last Updated: Jul 8, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
05:25

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft

Published on: September 15, 2023

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
09:12

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery

Published on: March 27, 2018

A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats
09:54

A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats

Published on: March 23, 2018

Area of Science:

  • Cardiovascular Surgery
  • Immunology
  • Hematology

Background:

  • Inflammatory responses are a concern in cardiac surgery.
  • On-pump and off-pump coronary artery bypass grafting (CABG) techniques have different procedural implications.

Purpose of the Study:

  • To compare the inflammatory response between on-pump and off-pump CABG.
  • To investigate the impact of cardiopulmonary bypass on complement activation.

Main Methods:

  • Prospective randomized study of 44 patients undergoing elective CABG.
  • Patients were randomized to on-pump (n=22) or off-pump (n=22) surgery.
  • Plasma markers of complement activation (C3bc, SC5b-9), neutrophil activation (myeloperoxidase), platelet activation (beta-thromboglobulin), and coagulation (F1 + 2) were measured pre-operatively and at multiple post-operative time points.

Main Results:

  • On-pump CABG showed significant complement activation (C3bc, SC5b-9; p < 0.001).
  • Off-pump CABG demonstrated no significant complement activation (p = 0.001 between groups).
  • Both groups exhibited similar neutrophil and platelet activation, but off-pump surgery showed enhanced coagulation (p < 0.01).

Conclusions:

  • Off-pump CABG effectively eliminates complement activation associated with the heart-lung machine.
  • Neutrophil and platelet activation are comparable between on-pump and off-pump CABG.
  • Coagulation activation is more pronounced following off-pump CABG.