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Updated: Jul 8, 2026

Characteristics of Precipitation-formed Polyethylene Glycol Microgels Are Controlled by Molecular Weight of Reactants

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Published on: December 23, 2013

Development of prednisone:polyethylene glycol 6000 fast-release tablets from solid dispersions: solid-state

Darío Leonardi¹, María Gabriela Barrera, María Celina Lamas

¹Departamento Farmacia, Facultad de Cs Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, IQUIOS, CONICET, Suipacha 531, 2000, Rosario, Argentina.

AAPS Pharmscitech

|January 10, 2008

Summary

This study developed fast-release prednisone tablets using solid dispersions with polyethylene glycol (PEG) 6000. Increasing PEG 6000 concentration significantly enhanced prednisone dissolution rates and tablet performance.

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Area of Science:

Pharmaceutical Sciences
Materials Science

Background:

Optimizing drug dissolution is crucial for oral fast-release formulations.
Prednisone's dissolution profile can be improved through advanced drug delivery systems.

Purpose of the Study:

To design and optimize oral fast-release polymeric tablets of prednisone.
To enhance prednisone dissolution by modifying carrier concentration in solid dispersions.

Main Methods:

Solid dispersions prepared using solvent evaporation at varying drug:polymer ratios.
Characterization via X-ray diffraction, infrared spectroscopy, and scanning electron microscopy.
Tablet formulation and dissolution testing.

Main Results:

Increasing polyethylene glycol (PEG) 6000 concentration significantly enhanced prednisone dissolution.
PEG 6000-based tablets showed 80% dissolution within 30 minutes, compared to <25% for conventional tablets.
Formulations demonstrated good disintegration and stability over 12 months.

Conclusions:

Polymeric solid dispersions, particularly with PEG 6000, are effective for improving prednisone dissolution.
Developed tablets offer a promising fast-release dosage form without superdisintegrants.
Prednisone remains stable within the PEG 6000 solid dispersion system.