Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...
Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH01:21

Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH

Drug absorption within the gastrointestinal (GI) tract is a complex process influenced by several critical factors, including the site pH, the drug's dissociation constant (pKa), and the drug's lipophilicity. The GI tract exhibits a pH gradient, with an acidic environment in the stomach and a more alkaline environment in the small intestine. This pH variation directly affects the ionization state of drugs.
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles in drug...
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of Inflammatory Markers With Symptomatic Intracranial Hemorrhage, Malignant Cerebral Edema, and Poor Functional Recovery in Patients With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy.

Journal of the American Heart Association·2026
Same author

Transcriptome-Metabolome Integration Reveals Key Regulators of Isoflavone Biosynthesis in Soybean for Enhanced Nutritional Quality.

Journal of agricultural and food chemistry·2026
Same author

A novel peptide mR<sub>63-77</sub> from Rpl36 protein showing potent antibacterial activities.

International journal of antimicrobial agents·2026
Same author

Perturbation of mitochondrial Ca<sup>2+</sup> homeostasis activates cross-compartmental proteostatic response in Arabidopsis.

Stress biology·2026
Same author

The impact of complementary interventions on pain and disability in patients with chronic non-cancer pain: A network meta-analysis.

Complementary therapies in clinical practice·2026
Same author

Neurological Complications and Surgical Outcomes in Infective Endocarditis.

Journal of the American Heart Association·2026

Related Experiment Video

Updated: Jul 8, 2026

Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization
09:35

Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization

Published on: December 25, 2017

Improved dissolution of oleanolic acid with ternary solid dispersions.

Longxiao Liu1, Xiaocui Wang

  • 1College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China. liulx@zju.edu.cn

AAPS Pharmscitech
|January 10, 2008
PubMed
Summary

This study improved oleanolic acid dissolution using solid dispersions with a polymer and surfactant. Ternary solid dispersions containing Polysorbate 80 showed faster oleanolic acid dissolution than binary ones.

More Related Videos

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Formation of Dispersible Taohong Siwu Tablets
05:44

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Related Experiment Videos

Last Updated: Jul 8, 2026

Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization
09:35

Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization

Published on: December 25, 2017

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Formation of Dispersible Taohong Siwu Tablets
05:44

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Materials Science

Background:

  • Oleanolic acid (OA) exhibits poor aqueous solubility, limiting its therapeutic applications.
  • Solid dispersion technology offers a promising approach to enhance the dissolution rate of poorly soluble drugs.
  • The role of surfactants in modifying drug crystallization and dissolution within solid dispersions requires further investigation.

Purpose of the Study:

  • To enhance the dissolution rate of oleanolic acid (OA) through the formulation of solid dispersions.
  • To investigate the impact of incorporating a surfactant (Polysorbate 80) on the properties and performance of OA solid dispersions.
  • To compare the dissolution enhancement efficacy of binary (drug-polymer) and ternary (drug-polymer-surfactant) solid dispersions.

Main Methods:

  • Preparation of binary solid dispersions of oleanolic acid and polyvinylpyrrolidone.
  • Formulation of ternary solid dispersions by incorporating Polysorbate 80 into binary systems.
  • Characterization of solid dispersions using differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR).
  • Evaluation of drug dissolution profiles through dissolution testing.

Main Results:

  • Solid dispersion formulations successfully inhibited the crystallization of oleanolic acid.
  • Both binary and ternary solid dispersions significantly enhanced the dissolution of oleanolic acid compared to the pure drug.
  • Ternary solid dispersions exhibited a markedly faster dissolution rate than binary solid dispersions.
  • Polysorbate 80 was identified as a key component contributing to the enhanced dissolution performance.

Conclusions:

  • Solid dispersion technology, particularly with the inclusion of Polysorbate 80, is effective in improving oleanolic acid dissolution.
  • Ternary solid dispersions offer superior dissolution enhancement for oleanolic acid over binary systems.
  • Polysorbate 80 plays a crucial role in facilitating the dissolution of oleanolic acid from solid dispersion formulations.