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Cutaneous malakoplakia.

Shane K Kohl1, Christine P Hans

  • 1Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198-3135, USA.

Archives of Pathology & Laboratory Medicine
|January 10, 2008
PubMed
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Malakoplakia is a rare granulomatous disorder affecting macrophages. This review details the clinical, microscopic, and treatment aspects of cutaneous malakoplakia, a seldom-seen manifestation.

Area of Science:

  • Dermatology
  • Pathology
  • Immunology

Background:

  • Malakoplakia is an acquired granulomatous disorder of unclear pathogenesis, often linked to macrophage dysfunction in immunosuppressed individuals or those with autoimmune diseases.
  • While commonly found in the genitourinary tract, malakoplakia can manifest in various anatomical sites.
  • Histologically, it is characterized by von Hansemann cells and Michaelis-Gutmann bodies.

Purpose of the Study:

  • To review the clinical, gross, and microscopic features of cutaneous malakoplakia.
  • To summarize treatment and prognosis based on reported cases.
  • To consolidate understanding of this rare skin manifestation.

Main Methods:

  • Literature review of cutaneous malakoplakia cases.
  • Analysis of clinical presentations.

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  • Examination of histopathological findings.

    • Main Results:

    • Cutaneous malakoplakia is a rare condition, with fewer than 50 cases previously reported.
    • This review analyzes 40 identified cases of cutaneous malakoplakia.
    • The study details the diverse clinical and microscopic characteristics observed.

    Conclusions:

    • Cutaneous malakoplakia is an uncommon but recognized entity.
    • Understanding its features is crucial for diagnosis and management.
    • Further research may elucidate its specific pathogenesis in the skin.