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Antigenic variation of a major surface glycoprotein of Pneumocystis carinii
1Department of Pediatrics, University of Rochester, NY 14642.
The Journal of Protozoology
|November 1, 1991
Abstract:
The mannosylated surface glycoprotein (gp) of Pneumocystis carinii has one known conserved epitope that is recognized by the monoclonal antibody 85-1-5E12. The gp exhibits host species-specific antigenic variation, exhibits host species-specific collagenase sensitivity, and varies in size depending on the host of origin and the method of preparation. These data support the existence of host species-specific serotypes of P. carinii.