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Ischemic Stroke l: Introduction

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

Hemorrhagic Stroke ll: Pathophysiology

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

Hemorrhagic Stroke l: Introduction

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

Stroke: Introduction and Types

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...

Transient Ischemic Attack l: Introduction

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...

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Related Experiment Video

Updated: Jul 8, 2026

Photothrombotic Ischemia: A Minimally Invasive and Reproducible Photochemical Cortical Lesion Model for Mouse Stroke Studies

Photothrombotic Ischemia: A Minimally Invasive and Reproducible Photochemical Cortical Lesion Model for Mouse Stroke Studies

Published on: June 9, 2013

Coated-platelets in ischemic stroke: differences between lacunar and cortical stroke.

C I Prodan¹, P M Joseph, A S Vincent

¹VA Medical Center, Oklahoma City, OK, USA. calin-prodan@ouhsc.edu

Journal of Thrombosis and Haemostasis : JTH

|January 10, 2008

Summary

This summary is machine-generated.

Coated-platelet production is significantly lower in patients with lacunar stroke compared to controls and cortical stroke patients. This finding suggests distinct pathological processes in stroke subtypes.

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Photothrombotic Ischemia: A Minimally Invasive and Reproducible Photochemical Cortical Lesion Model for Mouse Stroke Studies

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Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

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Published on: July 31, 2014

Area of Science:

Hematology
Neurology
Thrombosis

Background:

Coated-platelets are a platelet subset exhibiting procoagulant properties.
Their generation is triggered by dual agonist stimulation (collagen and thrombin).

Purpose of the Study:

To compare coated-platelet production in lacunar ischemic stroke patients versus non-lacunar (cortical) ischemic stroke patients and controls.
To investigate potential differences in coated-platelet synthesis between stroke subtypes.

Main Methods:

Analysis of blood samples from 60 ischemic stroke patients (20 lacunar, 40 cortical) and 70 controls.
Quantification of coated-platelet production using flow cytometry or similar assays.

Main Results:

Coated-platelet production was significantly lower in lacunar stroke patients (21.8%) compared to controls (31.6%, P = 0.008).
Cortical stroke patients showed significantly higher coated-platelet production (39.4%) than controls (P = 0.008).
Lacunar stroke patients had lower coated-platelet levels than cortical stroke patients (P < 0.001).

Conclusions:

Distinct differences in coated-platelet synthesis exist between lacunar and non-lacunar ischemic stroke.
These findings support the hypothesis of separate pathological mechanisms underlying lacunar and cortical stroke.
Further research into the role of coated-platelets in different stroke types is recommended.