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Related Experiment Videos

The Peter Pan paradigm.

J Craig Cohen1, Janet E Larson

  • 1The Brady Laboratory, Section of Neonatology, Department of Pediatrics, Stony Brook University Medical Center, Stony Brook, NY 11794, USA. jcraig.cohen@stonybrook.edu

Theoretical Biology & Medical Modelling
|January 10, 2008
PubMed
Summary
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Developmental delays during organogenesis can lead to functionally immature tissues at birth. These under-developed organs may present as normal initially but can cause progressive adult-onset pathology, necessitating a systems biology approach.

Area of Science:

  • Developmental biology
  • Pathology
  • Systems biology

Background:

  • Organogenesis can be disrupted by genetic and environmental factors.
  • The impact of developmental delays on postnatal organ function is not well understood.
  • Impaired organ development may lead to delayed-onset or progressive adult pathologies.

Purpose of the Study:

  • To explore the role of delayed development in organogenesis.
  • To investigate the long-term consequences of functionally immature tissues at birth.
  • To highlight the need for a systems biology approach in studying the maternal-fetal environment's impact on organ development.

Main Methods:

  • Review of existing evidence on organogenesis insults.
  • Analysis of the progression of pathology in under-developed organs.

Related Experiment Videos

  • Conceptual framework for a systems biology approach.

    • Main Results:

    • Delayed development, rather than direct insults, can result in functionally immature organs.
    • These organs may exhibit normal histology at birth but deteriorate with age.
    • Progressive or adult-onset pathology can arise from early developmental delays.

    Conclusions:

    • Developmental timing is critical for ensuring mature organ function.
    • Under-developed organs pose a risk for future health complications.
    • A comprehensive systems biology approach is required to understand the maternal-fetal environment's influence on organogenesis and long-term health outcomes.