Related Experiment Video
Updated: Jul 8, 2026
10:54
Optimization of Radiochemical Reactions using Droplet Arrays
Published on: February 12, 2021
NIR chemical imaging to guide/support BMS-561389 tablet formulation development.
L R Hilden1, C J Pommier, S I F Badawy
1Bristol-Myers Squibb Co, New Brunswick, NJ 08903-0191, USA. Hilden_Lori_R@lilly.com
International Journal of Pharmaceutics
|January 10, 2008
Summary
Smaller tartaric acid particle size improves uniform distribution in BMS-561389 tablets. Near-infrared imaging confirmed that the smallest particles showed no significant difference in distribution between tablet tops and bottoms.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Uniform drug distribution is critical for tablet efficacy.
- Particle size significantly influences powder blend homogeneity.
Purpose of the Study:
- To investigate the impact of tartaric acid particle size on its distribution uniformity in BMS-561389 tablets.
- To assess the feasibility of using near-infrared (NIR) chemical imaging for this analysis.
Main Methods:
- Three batches of BMS-561389 tablets were produced using tartaric acid with varying particle sizes.
- NIR chemical imaging was employed to map tartaric acid distribution on tablet surfaces.
- Image analysis software (ISys 3.1) was used for data processing and analysis.
Main Results:
- NIR imaging successfully mapped tartaric acid particles on tablet surfaces.
- Tartaric acid particle size correlated well with pre-compaction measurements.
- Significant segregation of tartaric acid was observed in tablets with larger and intermediate particle sizes.
Conclusions:
- Tartaric acid particle size critically affects its distribution uniformity in BMS-561389 tablets.
- Smaller tartaric acid particles lead to more uniform distribution, minimizing segregation.
- NIR chemical imaging is a viable technique for assessing particle distribution in tablets.
