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Updated: Jul 8, 2026
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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Fast dispersible/slow releasing ibuprofen tablets
Adamo Fini1, Valentina Bergamante, Gian Carlo Ceschel
1Dipartimento SMETEC, University of Bologna, Bologna, Italy. adamo.fini@unibo.it <adamo.fini@unibo.it>
Summary
New orally disintegrating tablets successfully mask ibuprofen's bitter taste using Phospholipon 80H and film coatings. These formulations provide controlled ibuprofen release, meeting disintegration standards for effective oral drug delivery.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Formulation Science
Background:
- Ibuprofen's bitter taste and side effects necessitate taste-masking and controlled release strategies.
- Orally disintegrating tablets (ODTs) offer improved patient compliance for oral medications.
Purpose of the Study:
- To develop and characterize ibuprofen ODTs with taste-masking and delayed drug release.
- To evaluate the impact of lecithin association and film coatings on ODT properties.
Main Methods:
- Eight ODT formulations of ibuprofen were prepared using wet granulation with Phospholipon 80H (lecithin).
- Granules were coated with various film-forming agents and then formulated with sweeteners, diluents, and superdisintegrants.
- Technological parameters, including wetting, disintegration time, and dissolution profiles, were assessed.
Main Results:
- Most formulations met European Pharmacopoeia (EP IV Ed.) requirements for wetting and disintegration.
- Coating and lecithin association effectively delayed ibuprofen release compared to free drug or simple granules.
- ODTs with delayed release characteristics were successfully produced using conventional techniques.
Conclusions:
- A combination of Phospholipon 80H and specific film coatings enables the creation of ibuprofen ODTs with masked taste and controlled release.
- The developed ODTs demonstrate suitability for oral administration, balancing disintegration properties with delayed drug release.
- This approach offers a viable method for formulating challenging drugs into ODTs with enhanced characteristics.
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