Related Experiment Video
Updated: Jul 8, 2026

Venous Thrombosis Assay in a Mouse Model of Cancer
Published on: January 5, 2024
[Changes of prethrombotic state indexes in patients with malignant cancer]
Shajidan Abudoureyimu1, Hong-liang Zhang, Renaguli Aizezi
1Department of Immunology, Xinjiang Medical University, Xinjiang Autonomous Region, Urumqi 830054, China.
Objective:
To study the changes and significance of prethrombotic state indexes in patients with malignant cancer.
Methods:
The expression of CD62p on platelets, level of plasma tissue plasminogen activator (t-PA), level of serum endothelin (ET-1), activated partial thromboplastin time (APTT), fibrinogen ( FIB), prothrombin time (PT), and thrombin time (TT) were examined by flow cytometer, enzyme-linked immunosorbent assay, radioimmunoassay method, and auto coagulometer.
Results:
The average expression of CD62P, level of plasma FIB and serum ET-1 in the tumor group increased compared with those in the control group (P<0.05); the level of t-PA in the tumor group decreased compared with that in the control group (P<0.05). APTT and PT were significantly shortened in the tumor group (P<0.05). There was no significant changes of TT in 2 groups (P>0.05).
Conclusion:
The platelet is activated, the thrombin activity increases, and the fibrinolytic function declines in patients with malignant cancer; there is an obvious prethrombotic state in patients with malignant cancer.
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