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Published on: June 16, 2020
Sirolimus-induced inflammatory papules with acquired reactive perforating collagenosis
1Clinique et Policlinique de Dermatologie et Vénéréologie, Hôpital Cantonal Universitaire de Genève, Geneva, Switzerland. jann.lubbe@hcuge.ch
Abstract:
Sirolimus is an immunosuppressive macrolide with antineoplasic properties that is increasingly used in posttransplantation immunosuppression. The treatment is frequently associated with cutaneous side effects such as sirolimus-associated acneiform facial dermatitis, which has been observed in up to 50% of treated patients. We report a 51-year-old female with liver transplantation who developed inflammatory papules and nodules on the face and the upper chest 3 weeks after the initiation of sirolimus therapy. Sequential biopsies revealed lymphocytic infiltration of the dermis with a peculiar pattern of sebotropism, while older lesions showed acquired reactive perforating collagenosis. The lesions were responsive to hydroxychloroquine treatment despite continued sirolimus treatment.
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