Related Experiment Video
Updated: Jul 8, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
[Treatment of osteoporosis with parathyroid hormone]
1Avdeling for endokrinologi, St. Olavs Hospital, 7006 Trondheim. unni.syversen@ntnu.no
Background:
Until recently, antiresorptive therapy has been the only treatment of osteoporosis. Parathyroid hormone (PTH) represents a new treatment principle. PTH given intermittently stimulates the osteoblasts and bone formation. We here present the effect of PTH on bone metabolism, bone mineral density and fracture reduction, and discuss the role of PTH in osteoporosis treatment.
Material And Methods:
The article is based on literature retrieved from Pubmed/Medline and on own experience from participation in multicentre studies.
Results And Interpretation:
Treatment with PTH stimulates bone formation and causes a more pronounced increase in bone mineral density than bisphosphonates and results in a significant reduction of vertebral and nonvertebral fractures. The treatment is very expensive, and is therefore used and reimbursed restrictively.
Related Concept Videos
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
The Parathyroid Glands
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Bone Remodeling
Skeleton and Calcium Homeostasis
Synthesis and Functions of Calcitonin
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...