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Platelet surface glycoprotein changes in patients with cerebral ischemia
C Legrand1, F Woimant, M Haguenau
1INSERM U 150, Hôpital Lariboisière, Paris, France.
Nouvelle Revue Francaise D'Hematologie
|January 1, 1991
Summary
Platelet activation and fragmentation may occur in patients after acute stroke, indicating potential thrombosis risk. These findings highlight circulating platelet alterations in ischemic cerebrovascular disease.
Area of Science:
- Hematology
- Neurology
- Cardiovascular Research
Background:
- In vitro studies suggest platelet abnormalities in ischemic cerebrovascular disease (ICD).
- Platelet receptors and alpha-granule release may be altered in the circulation of ICD patients.
Purpose of the Study:
- To investigate the frequency of platelet alterations in patients shortly after acute stroke.
- To identify potential biomarkers for thrombosis risk in acute stroke.
Main Methods:
- Studied 95 patients within days of acute stroke.
- Used antibodies to measure platelet surface expression of thrombospondin (TSP), GPIIb-IIIa, and GPIV.
- Assessed in vivo platelet secretion and changes in plasma membrane glycoproteins.
Main Results:
- 16 patients showed increased TSP, indicating in vivo platelet secretion and potential thrombosis risk.
- 20 patients exhibited decreased GPIIb-IIIa and GPIV, associated with reduced platelet volume, suggesting platelet fragmentation.
Conclusions:
- Circulating platelet alterations, including secretion and fragmentation, are detectable after acute stroke.
- These changes may represent distinct pathophysiological pathways and potential markers for thrombosis risk in ischemic cerebrovascular disease.