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Rearrangement of the E2A gene in the t (1;19) acute lymphoblastic leukemia
1INSERM U 301, Paris, France.
Nouvelle Revue Francaise D'Hematologie
|January 1, 1991
Abstract:
Recent studies have demonstrated that the E2A gene encoding helix-loop-helix proteins E12/E47 is fused to a novel homeobox gene PBX1, as a result of the t (1;19) translocation observed in pre-B cell acute lymphoblastic leukemias. Molecular diagnostic techniques, including PCR, of the t (1;19) are now possible and provide an useful tool in conjunction with cytogenetics to identify involvement of E2A and PBX1 genes in acute lymphoblastic leukemia.