Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Estimating Population Standard Deviation01:26

Estimating Population Standard Deviation

When the population standard deviation is unknown and the sample size is large, the sample standard deviation s is commonly used as a point estimate of σ. However, it can sometimes under or overestimate the population standard deviation. To overcome this drawback, confidence intervals are determined to estimate population parameters and eliminate any calculation bias accurately. However, this only applies to random samples from normally distributed populations. Knowing the sample mean and...
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
Estimating Population Mean with Known Standard Deviation01:16

Estimating Population Mean with Known Standard Deviation

To construct a confidence interval for a single unknown population mean μ, where the population standard deviation is known, we need sample mean as an estimate for μ and we need the margin of error. Here, the margin of error (EBM) is called the error bound for a population mean (abbreviated EBM). The sample mean is the point estimate of the unknown population mean μ.
The confidence interval estimate will have the form as follows:
(point estimate - error bound, point estimate + error bound)
The...
Estimating Population Mean with Unknown Standard Deviation01:22

Estimating Population Mean with Unknown Standard Deviation

In practice, we rarely know the population standard deviation. In the past, when the sample size was large, this did not present a problem to statisticians. They used the sample standard deviation s as an estimate for σ and proceeded as before to calculate a confidence interval with close enough results. However, statisticians ran into problems when the sample size was small. A small sample size caused inaccuracies in the confidence interval.
William S. Gosset (1876–1937) of the Guinness...
Statistical Inference Techniques in Hypothesis Testing: Parametric Versus Nonparametric Data01:16

Statistical Inference Techniques in Hypothesis Testing: Parametric Versus Nonparametric Data

Statistical inference techniques, paramount in hypothesis testing, differentiate into two broad categories: parametric and nonparametric statistics.
Parametric statistics, as the name suggests, assumes that data follow a specific distribution, often a normal distribution. This assumption enables robust hypothesis testing and estimation. Parametric methods, like the Student's t-test or Goodness-of-fit test, are frequently employed in biostatistics due to their robustness. For instance, comparing...
Econometric Views (EViews)01:29

Econometric Views (EViews)

Econometric Views, often stylized as EViews, is a package that merges statistical analysis with econometric studies. It is designed to provide tools for time series analysis, forecasting, and econometric model simulation. The software originated from MicroTSP software and has evolved significantly since its inception in 1981. The history of EViews is marked by a continuous effort to enhance its computational speed and user interface. It was initially developed for large computing systems but...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Maternal adverse childhood experiences and preschool children's behavioral problems: exploring mediation via an adapted measure of adult attachment pattern.

Frontiers in psychology·2026
Same author

Errors-in-variables regression as a viable approach to mediation analysis with random error-tainted measurements: Estimation, effectiveness, and an easy-to-use implementation.

Behavior research methods·2025
Same author

Maternal adverse childhood experiences and preschool children's behavioral problems: exploring mediation via an adapted measure of adult attachment pattern.

Frontiers in psychology·2025
Same author

Questions of value, questions of magnitude: An exploration and application of methods for comparing indirect effects in multiple mediator models.

Behavior research methods·2022
Same author

Mediation, Moderation, and Conditional Process Analysis: Concepts, Computations, and Some Common Confusions.

The Spanish journal of psychology·2022
Same author

Longitudinal partially ordered data analysis for preclinical sarcopenia.

Statistics in medicine·2020

Related Experiment Video

Updated: Jul 8, 2026

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

Using heteroskedasticity-consistent standard error estimators in OLS regression: an introduction and software

Andrew F Hayes1, Li Cai

  • 1School of Communication, Ohio State University, Columbus 43210, USA. hayes.338@osu.edu

Behavior Research Methods
|January 11, 2008
PubMed
Summary

Heteroskedasticity violates ordinary least squares (OLS) regression assumptions, biasing standard errors. Using heteroskedasticity-consistent standard error estimators is recommended for accurate statistical inference in OLS regression.

Related Experiment Videos

Last Updated: Jul 8, 2026

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

Area of Science:

  • Statistics
  • Econometrics
  • Data Analysis

Background:

  • Homoskedasticity is a key assumption in ordinary least squares (OLS) regression.
  • Violating this assumption can lead to biased covariance matrix estimators.
  • This bias affects the reliability of significance tests and confidence intervals in OLS regression.

Purpose of the Study:

  • To explain heteroskedasticity and its impact on OLS regression inference.
  • To introduce a family of heteroskedasticity-consistent standard error estimators.
  • To advocate for the routine use of these estimators in OLS hypothesis testing.

Main Methods:

  • Description of heteroskedasticity and its inferential consequences.
  • Discussion of heteroskedasticity-consistent standard error estimators.
  • Development of SPSS and SAS macros for practical implementation.

Main Results:

  • Heteroskedasticity leads to biased standard errors in OLS regression.
  • Heteroskedasticity-consistent standard errors provide more reliable inference.
  • Provided macros facilitate the application of these robust methods.

Conclusions:

  • Investigators should routinely employ heteroskedasticity-consistent standard errors for OLS regression.
  • These estimators ensure valid hypothesis testing and confidence intervals.
  • Implementation is simplified through provided SPSS and SAS macros.