Related Experiment Video
Updated: Jul 8, 2026
07:38
Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
Published on: May 6, 2018
Aprotinin and renal dysfunction after pediatric cardiac surgery
Andrea Székely1, Erzsébet Sápi, Tamás Breuer
1Department of Paediatric Anaesthesia and Intensive Care, Gottsegen György National Institute of Cardiology, Budapest, Hungary. szekelya@kardio.hu
Paediatric Anaesthesia
|January 11, 2008
Summary
Aprotinin use in pediatric cardiac surgery did not independently increase the risk of renal dysfunction or dialysis, despite higher observed incidences. The drug did reduce postoperative bleeding in these patients.
Area of Science:
- Cardiology
- Nephrology
- Pharmacology
Background:
- Aprotinin is an antifibrinolytic drug used to reduce bleeding and transfusion needs.
- Concerns exist regarding aprotinin's potential to cause renal dysfunction in adults.
- This study investigated aprotinin's safety in pediatric cardiac surgery.
Purpose of the Study:
- To assess the safety of aprotinin in pediatric patients undergoing cardiac surgery.
- To determine if aprotinin administration is independently associated with renal dysfunction or dialysis post-cardiac surgery.
Main Methods:
- Prospective data collection from 657 pediatric cardiac surgery patients.
- Analysis using propensity-score adjustment and multivariable methods.
- Renal dysfunction defined as a 25% decrease in creatinine clearance (Ccr).
Main Results:
- Higher incidence of dialysis and renal dysfunction observed in the aprotinin group.
- Propensity-adjusted analyses showed no significant increased risk for dialysis or renal dysfunction.
- Aprotinin significantly reduced postoperative blood loss within 24 hours.
Conclusions:
- Aprotinin did not demonstrate an independent role in causing renal dysfunction or dialysis in pediatric cardiac surgery patients.
- Factors like CPB duration and inotropic support were main contributors to renal dysfunction.
- Aprotinin effectively reduced bleeding in the early postoperative period.
Related Concept Videos
01:28Cardiac Catheterization I: Pre-Procedure Overview
Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
01:26Pharmacokinetics in Pediatric Patients: Drug Excretion
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
01:26Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
01:20Acute Kidney Injury V: Interprofessional Care
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
01:16Kidney Transplant III: Nursing Management
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...