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Updated: Jul 8, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Prescription writing: CAPD and PD plus.

J A Diaz-Buxo¹

¹Fresenius Medical Care North America, Waltham, MA, USA. jose.diaz-buxo@fmc-na.com

Clinical Nephrology

|January 11, 2008

Summary

Optimizing prescriptions for automated peritoneal dialysis (APD) improves patient outcomes. Careful adjustments can minimize sodium loss and enhance dialysis effectiveness when standard CAPD is insufficient.

Area of Science:

Nephrology
Renal Replacement Therapy
Dialysis Technology

Background:

Continuous ambulatory peritoneal dialysis (CAPD) and automated peritoneal dialysis (APD) are key treatments for kidney failure.
Prescription formulation relies on equilibration dialysis principles.
Understanding patient transport is crucial for effective dialysis.

Purpose of the Study:

To evaluate the correlation between predicted and observed clearances and ultrafiltration in CAPD and APD.
To identify strategies for optimizing APD prescriptions.
To determine when PD plus is indicated over CAPD.

Main Methods:

Analysis of prescription formulations for CAPD and PD plus.
Comparison of predicted versus clinically observed clearances and ultrafiltration.

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Last Updated: Jul 8, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Investigation of the impact of dialysate flows and sodium sieving in APD.

Main Results:

Good correlation exists between predicted and observed clearances and ultrafiltration, especially in average transporters.
Higher dialysate flows in APD can reduce sodium removal due to sodium sieving.
Optimal APD prescriptions can minimize sodium sieving.

Conclusions:

APD prescriptions can be optimized to improve efficacy and minimize side effects like sodium loss.
PD plus is a viable option when CAPD cannot meet dialysis adequacy targets.