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Updated: Jul 8, 2026
08:15
Gastrointestinal Motility Monitor (GIMM)
Published on: December 1, 2010
Motilin
Pierre Poitras1, Theo L Peeters
1Centre Hospitalier de l'Université de Montréal, Canada. pierre.poitras@sympatico.ca
Current Opinion in Endocrinology, Diabetes, and Obesity
|January 11, 2008
Summary
Motilin, a digestive tract hormone, is being explored for new medical applications. Future research will focus on its interactions and the development of motilin receptor agonists or antagonists to treat motility disorders.
Area of Science:
- Gastroenterology
- Endocrinology
- Pharmacology
Background:
- Motilin is a hormone synthesized by duodenal endocrine cells.
- It plays a crucial role in regulating digestive tract motility.
Purpose of the Study:
- This review explores recent advancements regarding motilin.
- It highlights the potential impact of motilin in human medicine.
Main Methods:
- Literature review of new findings on motilin.
- Discussion of emerging pharmacological agents targeting motilin receptors.
Main Results:
- Motilin belongs to a peptide family including ghrelin and obestatin.
- Pharmacological motilin receptor agonists and antagonists are under development.
- Further characterization of motilin receptors is needed for drug design.
Conclusions:
- Motilin's interactions with ghrelin and obestatin present new avenues for basic research.
- Motilin receptor modulators may soon offer therapeutic solutions for digestive dysmotility.
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