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Related Concept Videos

Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Goiter01:27

Goiter

Goiter refers to an abnormal enlargement of the thyroid gland that may appear as a diffuse goiter (uniform enlargement) or nodular (single or multiple nodules). Functionally, it is classified as nontoxic (normal/low hormone levels) or toxic (excess hormone production).PathophysiologyDiffuse thyroid enlargement typically results from prolonged stimulation by thyroid-stimulating hormone (TSH) or TSH-like agents, commonly seen in hypothyroidism or iodine deficiency. In contrast, in hyperthyroid...
Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

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Related Experiment Video

Updated: Jul 8, 2026

Gasless Endoscopic Thyroidectomy via the Trans-Axillary Approach
05:10

Gasless Endoscopic Thyroidectomy via the Trans-Axillary Approach

Published on: September 15, 2023

Thyroid storm induced by blunt thyroid gland trauma.

Stylianos Delikoukos1, Fotios Mantzos

  • 1Department of Surgery, Halkis General Hospital, Halkis, Greece. morfula@otenet.gr

The American Surgeon
|January 12, 2008
PubMed
Summary

Blunt neck trauma can cause isolated thyroid gland injury, leading to severe bleeding and airway issues. This rare injury may trigger thyroid storm even in individuals without prior hyperthyroidism.

Area of Science:

  • Endocrinology
  • Trauma Surgery
  • Emergency Medicine

Background:

  • Isolated thyroid gland injury from blunt neck trauma is rare.
  • Thyroid storm is an uncommon complication, especially in patients without pre-existing hyperthyroidism.

Observation:

  • Four cases of isolated thyroid gland injury were identified among 231 neck trauma patients.
  • Two patients presented with simultaneous thyrotoxic crisis, confirmed by clinical and laboratory findings.
  • Massive gland hemorrhage and acute airway obstruction were noted in these cases.

Findings:

  • Blunt thyroid gland injury can lead to thyroid storm due to acinar rupture and hormone release.
  • Thyroid storm may occur in patients with no prior history of hyperthyroidism.
  • Surgical intervention (lobectomy, thyroidectomy) combined with medical management led to recovery.

Related Experiment Videos

Last Updated: Jul 8, 2026

Gasless Endoscopic Thyroidectomy via the Trans-Axillary Approach
05:10

Gasless Endoscopic Thyroidectomy via the Trans-Axillary Approach

Published on: September 15, 2023

Implications:

  • Clinicians should consider thyroid storm in blunt neck trauma patients with suspected thyroid injury, regardless of prior thyroid status.
  • Prompt diagnosis and management are crucial for potentially life-threatening outcomes.
  • This highlights the importance of thorough evaluation of the thyroid gland in blunt neck trauma.