Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Liver Regeneration

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...

Tissue Renewal without Stem Cells

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dose-de-escalated focal radiotherapy for primary cutaneous T-cell lymphoma: a lesion-based retrospective cohort study.

Acta oncologica (Stockholm, Sweden)·2026

Same author

The Art of Kandinsky: Lessons in the Invisible and the Real.

Practical radiation oncology·2026

Same author

Glowing Beauty: Collecting Uranium Glass-Dangerous Liaisons?

Practical radiation oncology·2026

Same author

Role of Radiotherapy in the Era of Novel Immune-Based Treatment Strategies for Multiple Myeloma.

Hematological oncology·2026

Same author

Radiotherapy for indolent primary cutaneous B-cell lymphoma: an international multicenter ILROG analysis.

Blood·2026

Same author

In Regard to Huang et al.

International journal of radiation oncology, biology, physics·2026

Search research articles

Related Experiment Video

Updated: Jul 8, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Published on: October 10, 2011

Stem cells, cell transplantation and liver repopulation.

Michael Oertel¹, David A Shafritz

¹Marion Bessin Liver Research Center, Division of Hepatology, Department of Medicine, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA. moertel@aecom.yu.edu

Biochimica Et Biophysica Acta

|January 12, 2008

Summary

Investigating liver regeneration, this study explores stem cell potential for liver repair. While mature hepatocytes regenerate the liver, oval cells and fetal liver cells show promise but have limitations for transplantation.

More Related Videos

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Published on: August 29, 2016

Isolation and Enrichment of Liver Progenitor Subsets Identified by a Novel Surface Marker Combination

Isolation and Enrichment of Liver Progenitor Subsets Identified by a Novel Surface Marker Combination

Published on: February 18, 2017

Related Experiment Videos

Last Updated: Jul 8, 2026

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Isolation of CD133+ Liver Stem Cells for Clonal Expansion

Published on: October 10, 2011

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Published on: August 29, 2016

Isolation and Enrichment of Liver Progenitor Subsets Identified by a Novel Surface Marker Combination

Isolation and Enrichment of Liver Progenitor Subsets Identified by a Novel Surface Marker Combination

Published on: February 18, 2017

Area of Science:

Hepatology
Stem Cell Biology
Regenerative Medicine

Background:

Liver transplantation is the sole option for end-stage liver disease and acute liver failure.
Limited donor availability necessitates alternative strategies like cell transplantation for liver regeneration.
The existence and role of adult hepatic stem cells remain controversial.

Purpose of the Study:

To review and compare different cell types for their potential in liver repopulation and regeneration.
To characterize the properties of potential stem cells and their ability to restore liver function post-transplantation.
To address the controversy surrounding hepatic stem cells in adult mammalian livers.

Main Methods:

Review of existing literature on liver regeneration and cell transplantation.
Characterization of mature hepatocytes, oval cells, fetal liver cells, mesenchymal stem cells, and embryonic stem cells.
Comparison of cell properties and repopulation efficiency in various liver injury models.

Main Results:

Mature hepatocytes regenerate the liver effectively after partial hepatectomy or toxic injury.
Oval cells act as facultative stem cells when hepatocyte proliferation is blocked but do not repopulate normal transplanted livers.
Early fetal liver cells can repopulate normal livers but may not be true stem cells; MSCs and ESCs show limited repopulation efficiency.

Conclusions:

No single cell type currently fulfills the criteria for ideal stem cell therapy in liver regeneration.
Further research is needed to understand and harness the potential of various stem cell sources for liver repair.
The suitability of different cell types for liver repopulation depends on the specific injury context and cell characteristics.